Mannitol-1-phosphate 5-dehydrogenase
| mannitol-1-phosphate 5-dehydrogenase | |||||||
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| Identifiers | |||||||
| EC number | 1.1.1.17 | ||||||
| CAS number | 9028-24-4 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction
- D-mannitol 1-phosphate + NAD+
D-fructose 6-phosphate + NADH + H+
Thus, the two substrates of this enzyme are D-mannitol 1-phosphate and NAD+, whereas its 3 products are fructose 6-phosphate, NADH and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD+ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.
References
- MARMUR J, HOTCHKISS RD (1955). "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214 (1): 383–96. PMID 14367396.
- Wolfe JB and Kaplan NO (1955). Wolff, Johnb; Kaplan, Nathano. eds. "Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli". Methods Enzymol. 1: 346–348. doi:10.1016/0076-6879(55)01050-1.
- Wolfe JB and Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218: 849–869.